Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells

Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells

PGC-1α, a key orchestrator of mitochondrial metabolism, plays a crucial role in governing the energetically demanding needs of retinal pigment epithelial cells (RPE). We previously showed that silencing <i>PGC-1α</i> induced RPE to undergo an epithelial-mesenchymal-transition (EMT). Here...

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Bibliographic Details
Main Authors: Daisy Y. Shu, Erik R. Butcher, Magali Saint-Geniez
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
retinal pigment epithelium (RPE)
metabolism
mitochondria
transforming growth factor-beta (TGFβ)
epithelial-mesenchymal transition (EMT)
bioenergetics
Online Access:https://www.mdpi.com/1422-0067/22/9/4701

Internet

https://www.mdpi.com/1422-0067/22/9/4701

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