Multi-Facial, Non-Peptidic α-Helix Mimetics
α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-08-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/4/3/540 |
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doaj-aca37ab80c6a4b6694f14d2107f06fdf |
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Article |
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doaj-aca37ab80c6a4b6694f14d2107f06fdf2020-11-24T21:38:18ZengMDPI AGBiology2079-77372015-08-014354055510.3390/biology4030540biology4030540Multi-Facial, Non-Peptidic α-Helix MimeticsMaryanna E. Lanning0Steven Fletcher1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USADepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USAα-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.http://www.mdpi.com/2079-7737/4/3/540α-helix mimeticprotein–protein interactionproteomimeticamphipathiccancerBcl-2HMD2BakBimp53 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maryanna E. Lanning Steven Fletcher |
| spellingShingle |
Maryanna E. Lanning Steven Fletcher Multi-Facial, Non-Peptidic α-Helix Mimetics Biology α-helix mimetic protein–protein interaction proteomimetic amphipathic cancer Bcl-2 HMD2 Bak Bim p53 |
| author_facet |
Maryanna E. Lanning Steven Fletcher |
| author_sort |
Maryanna E. Lanning |
| title |
Multi-Facial, Non-Peptidic α-Helix Mimetics |
| title_short |
Multi-Facial, Non-Peptidic α-Helix Mimetics |
| title_full |
Multi-Facial, Non-Peptidic α-Helix Mimetics |
| title_fullStr |
Multi-Facial, Non-Peptidic α-Helix Mimetics |
| title_full_unstemmed |
Multi-Facial, Non-Peptidic α-Helix Mimetics |
| title_sort |
multi-facial, non-peptidic α-helix mimetics |
| publisher |
MDPI AG |
| series |
Biology |
| issn |
2079-7737 |
| publishDate |
2015-08-01 |
| description |
α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix. |
| topic |
α-helix mimetic protein–protein interaction proteomimetic amphipathic cancer Bcl-2 HMD2 Bak Bim p53 |
| url |
http://www.mdpi.com/2079-7737/4/3/540 |
| work_keys_str_mv |
AT maryannaelanning multifacialnonpeptidicahelixmimetics AT stevenfletcher multifacialnonpeptidicahelixmimetics |
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