Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.

Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipie...

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Bibliographic Details
Main Authors: Alastair J Moss, Fiona P Gaughran, Aliyye Karasu, Anthony S Gilbert, Alex J Mann, Colin M Gelder, John S Oxford, Henry A Stephens, Rob Lambkin-Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23951151/pdf/?tool=EBI
Description
Summary:Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
ISSN:1932-6203

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