Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?

Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?

Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. Prion particles are assemblies formed from a misfolded, &#946;-sheet rich, aggregation-prone isoform (PrP<sup>Sc</sup>) of the host-encoded cellular prion protein (...

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Bibliographic Details
Main Authors: Angélique Igel-Egalon, Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Human Rezaei, Vincent Béringue
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Viruses
Subjects:
prion
PrP
amyloid
quasi-species
dynamics
Online Access:https://www.mdpi.com/1999-4915/11/5/429

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