Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo

Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo

2,3-Dehydrosilybin (DHS) was previously shown to chelate and reduce both copper and iron ions. In this study, similar experiments with 2,3-dehydrosilychristin (DHSCH) showed that this congener of DHS also chelates and reduces both metals. Statistical analysis pointed to some differences between both...

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Bibliographic Details
Main Authors: Zuzana Lomozová, Václav Tvrdý, Marcel Hrubša, Maria Carmen Catapano, Kateřina Macáková, David Biedermann, Radim Kučera, Vladimír Křen, Přemysl Mladěnka, Kateřina Valentová
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
flavonolignans
silymarin
milk thistle
dehydroflavonolignans
dehydrosilybin
dehydrosilychristin
Online Access:https://www.mdpi.com/2076-3921/10/5/679

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