Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13

Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13

Cytochrome P450 2A13 (CYP2A13), an extrahepatic enzyme mainly expressed in the human respiratory system, has been reported to mediate the metabolism and toxicity of cigarette smoke. We previously found that nicotine inhibited 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism by CYP2A13...

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Bibliographic Details
Main Authors: Minghui Ji, Yudong Zhang, Na Li, Chao Wang, Rong Xia, Zhan Zhang, Shou-Lin Wang
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Environmental Research and Public Health
Subjects:
cigarette smoke extract
nicotine
cytochrome P450 2A13
cytotoxicity
BEAS-2B cells
Online Access:https://www.mdpi.com/1660-4601/14/10/1221

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https://www.mdpi.com/1660-4601/14/10/1221

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