AIDing chromatin and transcription-coupled orchestration of immunoglobulin class switch recombination

AIDing chromatin and transcription-coupled orchestration of immunoglobulin class switch recombination

Secondary diversification of the antibody repertoire upon antigenic challenge, in the form of immunoglobulin heavy chain (IgH) class switch recombination (CSR) endows mature, naïve B cells in peripheral lymphoid organs with a limitless ability to mount an optimal humoral immune response, thus expedi...

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Bibliographic Details
Main Authors: Bharat eVaidyanathan, Wei-Feng eYen, Joseph ePucella, Jayanta eChaudhuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
DNA Repair
class switching
DNA recombination
R-loops
cytidine deamination
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00120/full

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