Elucidating the role of metal ions in carbonic anhydrase catalysis
Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enz...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18425-5 |
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doaj-ac6771c63a524fde9f72e8f71131a4d12021-09-12T11:49:09ZengNature Publishing GroupNature Communications2041-17232020-09-0111111010.1038/s41467-020-18425-5Elucidating the role of metal ions in carbonic anhydrase catalysisJin Kyun Kim0Cheol Lee1Seon Woo Lim2Aniruddha Adhikari3Jacob T. Andring4Robert McKenna5Cheol-Min Ghim6Chae Un Kim7Department of Physics, Ulsan National Institute of Science and Technology (UNIST)Department of Physics, Ulsan National Institute of Science and Technology (UNIST)Department of Physics, Ulsan National Institute of Science and Technology (UNIST)Department of Physics, Ulsan National Institute of Science and Technology (UNIST)Department of Biochemistry and Molecular Biology, College of Medicine, University of FloridaDepartment of Biochemistry and Molecular Biology, College of Medicine, University of FloridaDepartment of Physics, Ulsan National Institute of Science and Technology (UNIST)Department of Physics, Ulsan National Institute of Science and Technology (UNIST)Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enzyme.https://doi.org/10.1038/s41467-020-18425-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim |
| spellingShingle |
Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim Elucidating the role of metal ions in carbonic anhydrase catalysis Nature Communications |
| author_facet |
Jin Kyun Kim Cheol Lee Seon Woo Lim Aniruddha Adhikari Jacob T. Andring Robert McKenna Cheol-Min Ghim Chae Un Kim |
| author_sort |
Jin Kyun Kim |
| title |
Elucidating the role of metal ions in carbonic anhydrase catalysis |
| title_short |
Elucidating the role of metal ions in carbonic anhydrase catalysis |
| title_full |
Elucidating the role of metal ions in carbonic anhydrase catalysis |
| title_fullStr |
Elucidating the role of metal ions in carbonic anhydrase catalysis |
| title_full_unstemmed |
Elucidating the role of metal ions in carbonic anhydrase catalysis |
| title_sort |
elucidating the role of metal ions in carbonic anhydrase catalysis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-09-01 |
| description |
Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enzyme. |
| url |
https://doi.org/10.1038/s41467-020-18425-5 |
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