A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses.

A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses.

Many cellular processes pertinent for viral infection are regulated by the addition of small ubiquitin-like modifiers (SUMO) to key regulatory proteins, making SUMOylation an important mechanism by which viruses can commandeer cellular pathways. Epstein-Barr virus (EBV) is a master at manipulating o...

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Bibliographic Details
Main Authors: Carlos F De La Cruz-Herrera, Kathy Shire, Umama Z Siddiqi, Lori Frappier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6051671?pdf=render

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