Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

Abstract Background Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and mortality, but its heterogeneity challenges the identification of effective therapies. Defining subphenotypes with distinct prognoses or biologic features can improve therapeutic trials, but prior wor...

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Bibliographic Details
Main Authors: Neha A. Sathe, Leila R. Zelnick, Carmen Mikacenic, Eric D. Morrell, Pavan K. Bhatraju, J. Brennan McNeil, Susanna Kosamo, Catherine L. Hough, W. Conrad Liles, Lorraine B. Ware, Mark M. Wurfel
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Critical Care
Subjects:
Acute hypoxemic respiratory failure
Mechanical ventilation
Acute lung injury
ARDS
Endophenotypes
Online Access:https://doi.org/10.1186/s13054-021-03755-7

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