Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor (AI) -Resistant, Hormone Receptor-Positive Breast Cancer.

Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor (AI) -Resistant, Hormone Receptor-Positive Breast Cancer.

Aromatase inhibitors (AIs) effectively treat hormone receptor-positive postmenopausal breast cancer, but some patients do not respond to treatment or experience recurrence. Mechanisms of AI resistance include ligand-independent activation of the estrogen receptor (ER) and signaling via other growth...

Full description

Bibliographic Details
Main Authors: Toru Higuchi, Megumi Endo, Toru Hanamura, Tatsuyuki Gohno, Toshifumi Niwa, Yuri Yamaguchi, Jun Horiguchi, Shin-Ichi Hayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4882040?pdf=render

Internet

http://europepmc.org/articles/PMC4882040?pdf=render

Similar Items