Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs

We present here the calculation of the mean time to capture of a tethered ligand to the receptor. This calculation is then used to determine the shift in the partitioning between (1) free, (2) singly bound, and (3) doubly bound ligands in chemical equilibrium as a function of the length of the tethe...

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Main Authors:	Lu Shen, Caitlin G. Decker, Heather D. Maynard, Alex J. Levine
Format:	Article
Language:	English
Published:	Elsevier 2016-09-01
Series:	Data in Brief
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352340916303389

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spelling	doaj-ac51377005434eb5bb2b465a79376fe72020-11-25T00:09:21ZengElsevierData in Brief2352-34092016-09-018506515Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairsLu Shen0Caitlin G. Decker1Heather D. Maynard2Alex J. Levine3Department of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USADepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USADepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California, Los Angeles, CA 90095, USADepartment of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USA; Department of Physics & Astronomy, University of California, Los Angeles, CA 90095, USA; Department of Biomathematics, University of California, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California, Los Angeles, CA 90095, USA; Corresponding author at: Department of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USA.We present here the calculation of the mean time to capture of a tethered ligand to the receptor. This calculation is then used to determine the shift in the partitioning between (1) free, (2) singly bound, and (3) doubly bound ligands in chemical equilibrium as a function of the length of the tether. These calculations are used in the research article Fibroblast Growth Factor 2 Dimer with Superagonist in vitro Activity Improves Granulation Tissue Formation During Wound Healing (Decker et al., in press [1]) to explain quantitatively how changes in polymeric linker length in the ligand dimers modifies the efficacy of these molecules relative to that of free ligands. Keywords: Ligand bindinghttp://www.sciencedirect.com/science/article/pii/S2352340916303389
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lu Shen Caitlin G. Decker Heather D. Maynard Alex J. Levine
spellingShingle	Lu Shen Caitlin G. Decker Heather D. Maynard Alex J. Levine Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs Data in Brief
author_facet	Lu Shen Caitlin G. Decker Heather D. Maynard Alex J. Levine
author_sort	Lu Shen
title	Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
title_short	Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
title_full	Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
title_fullStr	Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
title_full_unstemmed	Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
title_sort	calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs
publisher	Elsevier
series	Data in Brief
issn	2352-3409
publishDate	2016-09-01
description	We present here the calculation of the mean time to capture of a tethered ligand to the receptor. This calculation is then used to determine the shift in the partitioning between (1) free, (2) singly bound, and (3) doubly bound ligands in chemical equilibrium as a function of the length of the tether. These calculations are used in the research article Fibroblast Growth Factor 2 Dimer with Superagonist in vitro Activity Improves Granulation Tissue Formation During Wound Healing (Decker et al., in press [1]) to explain quantitatively how changes in polymeric linker length in the ligand dimers modifies the efficacy of these molecules relative to that of free ligands. Keywords: Ligand binding
url	http://www.sciencedirect.com/science/article/pii/S2352340916303389
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Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs

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