A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood. Mono-ubiquitylation of histone H2B (H2Bub1) plays...

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Bibliographic Details
Main Authors: Miriam Sansó, Karen M Lee, Laia Viladevall, Pierre-Étienne Jacques, Viviane Pagé, Stephen Nagy, Ariane Racine, Courtney V St Amour, Chao Zhang, Kevan M Shokat, Beate Schwer, François Robert, Robert P Fisher, Jason C Tanny
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3410854?pdf=render

Internet

http://europepmc.org/articles/PMC3410854?pdf=render

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