Regulatory Role of Peritoneal B Cells in EAE

• Main Authors: Stojanović Bojana, Milovanović Jelena, Arsenijević Aleksandar, Milovanovic Marija, Lukic Miodrag L.
• Format: Article
• Language: English
• Published: Sciendo 2016-06-01
• Series: Serbian Journal of Experimental and Clinical Research
• Subjects: multiple sclerosis; eae; b cells; peritoneal regulatory b cells
• Online Access: https://doi.org/10.1515/sjecr-2015-0048
• ISSN: 1820-8665; 2335-075X

B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction.