Role of hepatitis B virus X protein in development and progression of primary liver cancer

Role of hepatitis B virus X protein in development and progression of primary liver cancer

Hepatitis B virus (HBV) X protein (HBx) is a multifunctional protein encoded by HBV X gene. It plays a regulatory role in gene transcription, cell signal transduction, cell proliferation and transformation, cell cycle, and cell apoptosis. Currently, HBx is considered to play an important role in the...

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Main Author: LIAO Kai
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2014-01-01
Series:Linchuang Gandanbing Zazhi
Subjects:
hepatitis B virus; bcl-2-associated X protein; carcinoma
hepatocellular
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=5659&ClassID=1230144627
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spelling doaj-ac3eb86b18914ba88c14fc24d3fa23652020-11-25T02:47:37ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562014-01-01301788110.3969/j.issn.1001-5256.2014.01.023Role of hepatitis B virus X protein in development and progression of primary liver cancerLIAO Kai0Department of Hepatobiliary Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, ChinaHepatitis B virus (HBV) X protein (HBx) is a multifunctional protein encoded by HBV X gene. It plays a regulatory role in gene transcription, cell signal transduction, cell proliferation and transformation, cell cycle, and cell apoptosis. Currently, HBx is considered to play an important role in the development and progression of HBV-related hepatocellular carcinoma (HCC). The relationship of HBx with oncogene, antioncogene, cell proliferation, cell apoptosis, invasion and metastasis of liver cancer, and liver cancer stem cells is presented, and the role of HBx in the development and progression of HCC is reviewed.http://www.lcgdbzz.org/qk_content.asp?id=5659&ClassID=1230144627hepatitis B virus; bcl-2-associated X protein; carcinomahepatocellular
collection DOAJ
language zho
format Article
sources DOAJ
author LIAO Kai
spellingShingle LIAO Kai
Role of hepatitis B virus X protein in development and progression of primary liver cancer
Linchuang Gandanbing Zazhi
hepatitis B virus; bcl-2-associated X protein; carcinoma
hepatocellular
author_facet LIAO Kai
author_sort LIAO Kai
title Role of hepatitis B virus X protein in development and progression of primary liver cancer
title_short Role of hepatitis B virus X protein in development and progression of primary liver cancer
title_full Role of hepatitis B virus X protein in development and progression of primary liver cancer
title_fullStr Role of hepatitis B virus X protein in development and progression of primary liver cancer
title_full_unstemmed Role of hepatitis B virus X protein in development and progression of primary liver cancer
title_sort role of hepatitis b virus x protein in development and progression of primary liver cancer
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2014-01-01
description Hepatitis B virus (HBV) X protein (HBx) is a multifunctional protein encoded by HBV X gene. It plays a regulatory role in gene transcription, cell signal transduction, cell proliferation and transformation, cell cycle, and cell apoptosis. Currently, HBx is considered to play an important role in the development and progression of HBV-related hepatocellular carcinoma (HCC). The relationship of HBx with oncogene, antioncogene, cell proliferation, cell apoptosis, invasion and metastasis of liver cancer, and liver cancer stem cells is presented, and the role of HBx in the development and progression of HCC is reviewed.
topic hepatitis B virus; bcl-2-associated X protein; carcinoma
hepatocellular
url http://www.lcgdbzz.org/qk_content.asp?id=5659&ClassID=1230144627
work_keys_str_mv AT liaokai roleofhepatitisbvirusxproteinindevelopmentandprogressionofprimarylivercancer
_version_ 1724752435485868032

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