The Usage of Human IGHJ Genes Follows a Particular Non-random Selection: The Recombination Signal Sequence May Affect the Usage of Human IGHJ Genes

The Usage of Human IGHJ Genes Follows a Particular Non-random Selection: The Recombination Signal Sequence May Affect the Usage of Human IGHJ Genes

The formation of the B cell receptor (BCR) heavy chain variable region is derived from the germline V(D)J gene rearrangement according to the “12/23” rule and the “beyond 12/23” rule. The usage frequency of each V(D)J gene in the peripheral BCR repertoires is related to the initial recombination, se...

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Bibliographic Details
Main Authors: Bin Shi, Xiaoheng Dong, Qingqing Ma, Suhong Sun, Long Ma, Jiang Yu, Xiaomei Wang, Juan Pan, Xiaoyan He, Danhua Su, Xinsheng Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Genetics
Subjects:
High-throughput sequencing
V(D)J
IGHJ
“12/23” rule
BCR
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.524413/full

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