Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps

Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors wer...

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Main Authors: Atakan Yesil, Gul Babacan Abanonu, Yasar Colak, Nurcan Paker, Can Gonen
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2013/275392
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spelling doaj-ac308fdab89a4ef199f362791d9f38552020-11-24T22:57:12ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/275392275392Prognostic Significance of DR-70 Levels in Dysplastic Colorectal PolypsAtakan Yesil0Gul Babacan Abanonu1Yasar Colak2Nurcan Paker3Can Gonen4Department of Gastroenterology, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Internal Medicine, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Gastroenterology, Medeniyet University, Istanbul, TurkeyDuzen Laboratories, Istanbul, TurkeyDepartment of Gastroenterology, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyBackground. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels. Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001). DR-70 was higher in group 1b as compared to group 1a (P<0.001). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001). Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.http://dx.doi.org/10.1155/2013/275392
collection DOAJ
language English
format Article
sources DOAJ
author Atakan Yesil
Gul Babacan Abanonu
Yasar Colak
Nurcan Paker
Can Gonen
spellingShingle Atakan Yesil
Gul Babacan Abanonu
Yasar Colak
Nurcan Paker
Can Gonen
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
Gastroenterology Research and Practice
author_facet Atakan Yesil
Gul Babacan Abanonu
Yasar Colak
Nurcan Paker
Can Gonen
author_sort Atakan Yesil
title Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
title_short Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
title_full Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
title_fullStr Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
title_full_unstemmed Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
title_sort prognostic significance of dr-70 levels in dysplastic colorectal polyps
publisher Hindawi Limited
series Gastroenterology Research and Practice
issn 1687-6121
1687-630X
publishDate 2013-01-01
description Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels. Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001). DR-70 was higher in group 1b as compared to group 1a (P<0.001). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001). Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.
url http://dx.doi.org/10.1155/2013/275392
work_keys_str_mv AT atakanyesil prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps
AT gulbabacanabanonu prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps
AT yasarcolak prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps
AT nurcanpaker prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps
AT cangonen prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps
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