Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors wer...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | Gastroenterology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2013/275392 |
id |
doaj-ac308fdab89a4ef199f362791d9f3855 |
---|---|
record_format |
Article |
spelling |
doaj-ac308fdab89a4ef199f362791d9f38552020-11-24T22:57:12ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/275392275392Prognostic Significance of DR-70 Levels in Dysplastic Colorectal PolypsAtakan Yesil0Gul Babacan Abanonu1Yasar Colak2Nurcan Paker3Can Gonen4Department of Gastroenterology, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Internal Medicine, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Gastroenterology, Medeniyet University, Istanbul, TurkeyDuzen Laboratories, Istanbul, TurkeyDepartment of Gastroenterology, Haydarpaşa Numune Training and Research Hospital, Istanbul, TurkeyBackground. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels. Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001). DR-70 was higher in group 1b as compared to group 1a (P<0.001). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001). Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.http://dx.doi.org/10.1155/2013/275392 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atakan Yesil Gul Babacan Abanonu Yasar Colak Nurcan Paker Can Gonen |
spellingShingle |
Atakan Yesil Gul Babacan Abanonu Yasar Colak Nurcan Paker Can Gonen Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps Gastroenterology Research and Practice |
author_facet |
Atakan Yesil Gul Babacan Abanonu Yasar Colak Nurcan Paker Can Gonen |
author_sort |
Atakan Yesil |
title |
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps |
title_short |
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps |
title_full |
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps |
title_fullStr |
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps |
title_full_unstemmed |
Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps |
title_sort |
prognostic significance of dr-70 levels in dysplastic colorectal polyps |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2013-01-01 |
description |
Background. To investigate the relationship between DR-70 serum levels and dysplastic colon polyps. Materials and Methods. A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study. Blood samples from each participant were analyzed for serum CEA and DR-70 levels. Results. No statistically significant differences were observed between the two groups in terms of age or gender. The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001). DR-70 was higher in group 1b as compared to group 1a (P<0.001). However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067). In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001). Conclusions. DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer. |
url |
http://dx.doi.org/10.1155/2013/275392 |
work_keys_str_mv |
AT atakanyesil prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps AT gulbabacanabanonu prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps AT yasarcolak prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps AT nurcanpaker prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps AT cangonen prognosticsignificanceofdr70levelsindysplasticcolorectalpolyps |
_version_ |
1725651392534675456 |