Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (P...

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Bibliographic Details
Main Authors: Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H. C. van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
peroxisome
β-oxidation
multifunctional protein 2
retina
photoreceptors
PUFA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.632930/full

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