3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation

Abstract. Background:. Pulmonary arterial hypertension (PH) is a progressive disease with limited therapeutic options, ultimately leading to right heart failure and death. Recent findings indicate the role of the Warburg effect (aerobic glycolysis) in the development of PH. However, the effect of th...

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Bibliographic Details
Main Authors: Jie Liu, Wang Wang, Lei Wang, Xian-Mei Qi, Yu-Hui Sha, Ting Yang, Qiang Shi
Format: Article
Language:English
Published: Wolters Kluwer 2020-01-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000000577