Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

Abstract Background As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety of stress conditions. HSF1 also plays a key role in regulating the devel...

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Bibliographic Details
Main Authors: Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He, Jinghong Yang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Heat shock factor 1
Heat shock proteins
Oncogene
SMAC
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13046-017-0537-x

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