Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells

Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells

Toxoplasma gondii secretes rhoptry (ROP) and dense granule (GRA) effector proteins to evade host immune clearance mediated by interferon gamma (IFN-γ), immunity-related GTPase (IRG) effectors, and CD8+ T cells. Here, we investigated the role of parasite-secreted effectors in regulating host access t...

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Bibliographic Details
Main Authors: Leah M. Rommereim, Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, David J. Bzik
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
dense granule
rhoptry
antigen presentation
immunity related GTPases
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02104/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02104/full

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