A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.

A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.

During the lytic phase of infection, the gamma herpesvirus Kaposi's Sarcoma-Associated Herpesvirus (KSHV) expresses a highly abundant, 1.1 kb nuclear noncoding RNA of unknown function. We observe that this polyadenylated nuclear (PAN) RNA avidly binds host poly(A)-binding protein C1 (PABPC1), w...

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Bibliographic Details
Main Authors: Sumit Borah, Nicole Darricarrère, Alicia Darnell, Jinjong Myoung, Joan A Steitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3192849?pdf=render

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