Aberrant Alternative Splicing Is Another Hallmark of Cancer

Aberrant Alternative Splicing Is Another Hallmark of Cancer

The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases...

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Main Author: Michael Ladomery
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:International Journal of Cell Biology
Online Access:http://dx.doi.org/10.1155/2013/463786
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spelling doaj-abdd2d9a07354f1aa53b39277ff8d19c2020-11-24T22:29:55ZengHindawi LimitedInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/463786463786Aberrant Alternative Splicing Is Another Hallmark of CancerMichael Ladomery0Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UKThe vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks.http://dx.doi.org/10.1155/2013/463786
collection DOAJ
language English
format Article
sources DOAJ
author Michael Ladomery
spellingShingle Michael Ladomery
Aberrant Alternative Splicing Is Another Hallmark of Cancer
International Journal of Cell Biology
author_facet Michael Ladomery
author_sort Michael Ladomery
title Aberrant Alternative Splicing Is Another Hallmark of Cancer
title_short Aberrant Alternative Splicing Is Another Hallmark of Cancer
title_full Aberrant Alternative Splicing Is Another Hallmark of Cancer
title_fullStr Aberrant Alternative Splicing Is Another Hallmark of Cancer
title_full_unstemmed Aberrant Alternative Splicing Is Another Hallmark of Cancer
title_sort aberrant alternative splicing is another hallmark of cancer
publisher Hindawi Limited
series International Journal of Cell Biology
issn 1687-8876
1687-8884
publishDate 2013-01-01
description The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks.
url http://dx.doi.org/10.1155/2013/463786
work_keys_str_mv AT michaelladomery aberrantalternativesplicingisanotherhallmarkofcancer
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