Protease circuits for processing biological information

Protease circuits for processing biological information

In contrast to genetic circuits, here the authors develop protein biocircuits based on proteases. They show these activity-based circuits can execute Boolean logic for programmable drug delivery and perform fuzzy logic to solve a mathematical oracle problem, Learning Parity with Noise.

Bibliographic Details
Main Authors: Brandon Alexander Holt, Gabriel A. Kwong
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18840-8
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spelling doaj-abcc36c96dcb48cfb602fde7368825972021-10-10T11:47:33ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-18840-8Protease circuits for processing biological informationBrandon Alexander Holt0Gabriel A. Kwong1Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory School of MedicineWallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory School of MedicineIn contrast to genetic circuits, here the authors develop protein biocircuits based on proteases. They show these activity-based circuits can execute Boolean logic for programmable drug delivery and perform fuzzy logic to solve a mathematical oracle problem, Learning Parity with Noise.https://doi.org/10.1038/s41467-020-18840-8
collection DOAJ
language English
format Article
sources DOAJ
author Brandon Alexander Holt
Gabriel A. Kwong
spellingShingle Brandon Alexander Holt
Gabriel A. Kwong
Protease circuits for processing biological information
Nature Communications
author_facet Brandon Alexander Holt
Gabriel A. Kwong
author_sort Brandon Alexander Holt
title Protease circuits for processing biological information
title_short Protease circuits for processing biological information
title_full Protease circuits for processing biological information
title_fullStr Protease circuits for processing biological information
title_full_unstemmed Protease circuits for processing biological information
title_sort protease circuits for processing biological information
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description In contrast to genetic circuits, here the authors develop protein biocircuits based on proteases. They show these activity-based circuits can execute Boolean logic for programmable drug delivery and perform fuzzy logic to solve a mathematical oracle problem, Learning Parity with Noise.
url https://doi.org/10.1038/s41467-020-18840-8
work_keys_str_mv AT brandonalexanderholt proteasecircuitsforprocessingbiologicalinformation
AT gabrielakwong proteasecircuitsforprocessingbiologicalinformation
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