Asthma and Influenza Virus Infection: Focusing on Cell Death and Stress Pathways in Influenza Virus Replication

• Main Authors: Behzad Yeganeh, Adel Rezaei Moghadam, Ahn Thuy Tran, Mohammad Niaz Rahim, Sudu R Ande, Mohammad Hashemi, Kevin M Coombs, Saeid Ghavami
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2013-03-01
• Series: Iranian Journal of Allergy, Asthma and Immunology
• Subjects: Apoptosis; Autophagy; Endoplasmic Reticulum Stress; Unfolded Protein Response; Virus-induced autophagy; Virus-induced apoptosis
• Online Access: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/539

Asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. Increasing reports have linked airway infectious diseases to asthma. Influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. Diverse host response pathways during virus infection have been identified, including different cell death and survival pathways. These pathways include 1) programmed cell death I (apoptosis), 2) programmed cell death II (autophagy), and 3) endoplasmic reticulum stress with subsequent unfolded protein response (UPR). There has been extensive research on the regulatory roles of these pathways during the influenza virus life cycle. These studies address the benefits of enhancing or inhibiting these pathways on viral replication. Here we review the most recent and significant knowledge in this area for possible  benefits  to  clinicians and  basic  scientist researchers  in  different  areas  of  the respiratory and virology sciences.