MC4R Is Involved in Neuropathic Pain by Regulating JNK Signaling Pathway After Chronic Constriction Injury

MC4R Is Involved in Neuropathic Pain by Regulating JNK Signaling Pathway After Chronic Constriction Injury

BackgroundNeuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and glia cells. Melanocortin 4 receptor (MC4R) is involved in the regulation of pain due to its high expressions in brain. Moreover, MC4R could mediate the c-Jun N-terminal kinase (JNK) signa...

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Bibliographic Details
Main Authors: Yang Zhao, Yan Xin, Haichen Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
neuropathic pain
melanocortin 4 receptor (MC4R)
JNK signaling pathway
chronic constriction injury
nociceptive behavior
paw withdrawal latency
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00919/full

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