Fundamental deficiencies in the megatrial methodology
<p>Abstract</p> <p>The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologically and prognostically heterogeneous subjects, and pr...
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| Format: | Article |
| Language: | English |
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BMC
2001-01-01
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| Series: | Current Controlled Trials in Cardiovascular Medicine |
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| Online Access: | http://cvm.controlled-trials.com/content/2/1/002 |