Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation

Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation

We accumulated mutations for 1952 generations in 79 initially identical, haploid lines of the fission yeast Schizosaccharomyces pombe, and then performed whole-genome sequencing to determine the mutation rates and spectrum. We captured 696 spontaneous mutations across the 79 mutation accumulation (M...

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Bibliographic Details
Main Authors: Megan G. Behringer, David W. Hall
Format: Article
Language:English
Published: Oxford University Press 2016-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
mutation accumulation
insertion bias
cytosine mutation
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.022129

Internet

http://g3journal.org/lookup/doi/10.1534/g3.115.022129

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