Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

<p>Abstract</p> <p>Background</p> <p>Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease. In addition to their cholesterol-lowering activities, statins exert pleiotropic...

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Bibliographic Details
Main Authors: Esposito Emanuela, Rinaldi Barbara, Mazzon Emanuela, Donniacuo Maria, Impellizzeri Daniela, Paterniti Irene, Capuano Annalisa, Bramanti Placido, Cuzzocrea Salvatore
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Neuroinflammation
Subjects:
SCI
PPAR-α
simvastatin
inflammation
Online Access:http://www.jneuroinflammation.com/content/9/1/81

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