Molecular study of the dentin-pulp complex responses to caries progression

• Main Author: Yani Corvianindya Rahayu
• Format: Article
• Language: English
• Published: Universitas Airlangga 2007-03-01
• Series: Dental Journal: Majalah Kedokteran Gigi
• Subjects: Dentin-pulp complex, Molecular events; Caries progression
• Online Access: http://e-journal.unair.ac.id/index.php/MKG/article/view/1065

<span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>The dentin-pulp complex exhibits various responses to caries, including events of injury, defense, and repair. The overall </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>responses dependent on pulp cell activity and the signaling processes, which regulate the behavior of these cells. The signals for tissue </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>repair are thought to be mediated by dentin-bound growth factors released during caries progression. Growth factors are a key of </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>molecules responsible for signaling a variety of cellular process following dental injury. The endogenous proteolytic enzymes (Matrix </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>metalloproteinases, MMPs) present in dentin matrix might also participate in releasing bioactive molecule. Several members of the </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>MMP family are found in the soft and hard tissue compartment of dentin-pulp complex. Their presumed role in many physiological </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>process during the development and maintenance of the dentin-pulp complex, they may also contribute to the pathogenesis of dentin </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>caries and the responses elicited by caries.</em></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span>