Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Abstract Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiological roles of cytoplasmic DNAs in leukemias remain l...

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Bibliographic Details
Main Authors: Tomohisa Baba, Takeshi Yoshida, Yamato Tanabe, Tatsunori Nishimura, Soji Morishita, Noriko Gotoh, Atsushi Hirao, Rikinari Hanayama, Naofumi Mukaida
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03587-x

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https://doi.org/10.1038/s41419-021-03587-x

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