Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some macrophages persist in the absence of CSF1R. Here, we analyzed mpeg1:GFP–expressing macrophages in csf1r-deficient zebrafish and report that embryoni...

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Bibliographic Details
Main Authors: Laura E Kuil, Nynke Oosterhof, Giuliano Ferrero, Tereza Mikulášová, Martina Hason, Jordy Dekker, Mireia Rovira, Herma C van der Linde, Paulina MH van Strien, Emma de Pater, Gerben Schaaf, Erik MJ Bindels, Valerie Wittamer, Tjakko J van Ham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
macrophages
hematopoiesis
langerhans cells
metaphocytes
CSF1R
microglia
Online Access:https://elifesciences.org/articles/53403

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