The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

Growing evidence has demonstrated that epigenetic dysregulation is a common pathological feature in human cancer cells. Global alterations in the epigenetic landscape are prevalent in malignant cells across different solid tumors including, prostate cancer, non-small-cell lung cancer, renal cell car...

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Bibliographic Details
Main Authors: Laura Monaghan, Matthew E. Massett, Roderick P. Bunschoten, Alex Hoose, Petrisor-Alin Pirvan, Robert M. J. Liskamp, Heather G. Jørgensen, Xu Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia (AML)
Leukaemic stem cell (LSC)
Histone 3 lysine 9 trimethylation (H3K9me3)
lysine specific demethylase (KDM)
heterochromatin
gene suppression
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00705/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00705/full

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