Role of Biochemical Investigations and Diagnostic Tools in Detection of Adverse Drug Reactions

• Main Authors: Vishal R. Tandon, Vijay Khajuria, Kapila Raina, Vivek Mahajan, Aman Sharma, Zahid Gillani
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2014-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: adverse drug reaction; biochemical investigations; diagnostic tools
• Online Access: https://jcdr.net/articles/PDF/4907/8487_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh)_PF2(PAG).pdf

Aim of Study: To evaluate the role of biochemical investigations (BI) and diagnostic tools (DT) in ADR detection Materials and Methods: An observational prospective crosssectional study was done using suspected ADR data collection form. Results: A total of 2381 ADR related events were recorded in two years. Total number/percentage of biochemical abnormalities (BA) related ADR detection rate was 14.57% and of DT was 1.091% in contrast to 84.33% recorded with clinical presentation. Maximum cases were inward patients (87.13%), 67.02% were recorded by active surveillance. ADR detection rate at one point & detection on follow up was 56.31% Vs 46.38%. ADR detection rate of ECG, endoscopy, X-ray were 0.57%, 0.22%, 0.22% and of CT scan, MRI, DEXA scan, USG and biopsy was 0.04% each. Maximum ADRs were severe/serious, latent and Type-A in nature. Anemia (4.6%), followed by liver dysfunction (2.8%), renal dysfunction, electrolyte imbalance, hyperglycemia (1.1% each), abnormal coagulation profile (1%), decrease platelet count (0.8%), hypoglycemia (0.7%) were the most common BAs. Anti retroviral drugs (ART), tirofiban and methotrexate accounted for anemia, ART and anti tubercular drugs for liver & renal dysfunction, insulin for hypoglycemia, tirofiban, paclitaxel, capecipabine and ifosfamide for thrombocytopenia, hematuria by enoxaparin & dyslipidemia with ART were common ADRs. Conclusion: BI and DT can play very important role in ADR detection.