Saikosaponin A attenuates neural injury caused by ischemia/reperfusion

Saikosaponin A attenuates neural injury caused by ischemia/reperfusion

Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemi...

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Bibliographic Details
Main Authors: Wang Xinying, Yang Guofeng
Format: Article
Language:English
Published: De Gruyter 2020-07-01
Series:Translational Neuroscience
Subjects:
ischemia
neuroprotection
stroke
toll-like receptors
hmgb1
Online Access:https://doi.org/10.1515/tnsci-2020-0129
Description
Summary:Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemic stroke and the underlying mechanism.
ISSN:2081-6936

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