T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease.

T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease.

Patients with Alzheimer's disease (AD) exhibit substantial accumulation of amyloid-beta (Abeta) plaques in the brain. Here, we examine whether Abeta vaccination can facilitate the migration of T lymphocytes to specifically target Abeta plaques and consequently enhance their removal. Using a new...

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Bibliographic Details
Main Authors:	Yair Fisher, Anna Nemirovsky, Rona Baron, Alon Monsonego
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2877087?pdf=render

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