Karakterisasi Kompleks Inklusi Asam Mefenamat - β -Siklodekstrin yang Dibuat dengan Metode Freeze Drying
<p>Characterization of mefenamic acid-β-cyclodextrin inclusion complexes by freeze drying method had been studied. Solid state mefenamic acid- β-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamic acid, β-cyclodextrin, mefenamic acid-β-cyclodextrin phy...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Badan Penelitian dan Pengembangan Kesehatan
2012-10-01
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| Series: | Jurnal Kefarmasian Indonesia |
| Online Access: | http://ejournal.litbang.kemkes.go.id/index.php/jki/article/view/1290 |
| Summary: | <p>Characterization of mefenamic acid-β-cyclodextrin inclusion complexes by freeze drying method had been studied. Solid state mefenamic acid- β-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamic acid, β-cyclodextrin, mefenamic acid-β-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) , Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and β-cyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid-β-cyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid-β-cyclodextrin inclusion complex showed increasing dissolution rate compared to mefenamic acid-β-cyclodextrin physical mixture and mefenamic acid.</p> <p> </p> <p>Key words: mefenamic acid, β-cyclodextrin, freeze drying, inclusion complex, dissolution rate</p> |
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| ISSN: | 2085-675X 2354-8770 |