Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits

Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits

Abstract Background Prostate tumor over expressed gene 1 (PTOV1) has been reported as an oncogene in several human cancers. However, the clinical significance and biological role of PTOV1 remain elusive in non-small cell lung cancer (NSCLC). Methods The Cancer Genome Atlas (TCGA) data and NCBI/GEO d...

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Bibliographic Details
Main Authors: Zhiqiang Wu, Zhuang Liu, Xiangli Jiang, Zeyun Mi, Maobin Meng, Hui Wang, Jinlin Zhao, Boyu Zheng, Zhiyong Yuan
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Non-small cell lung cancer
PTOV1
Chemotherapy
Cancer stem cell
β-Catenin
Online Access:http://link.springer.com/article/10.1186/s13046-019-1349-y

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