Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesi...

Full description

Bibliographic Details
Main Authors: Gennaro Piccialli, Luciano Mayol, Michela Varra, Giorgia Oliviero, Nicola Borbone, Jussara Amato, Vincenzo Piccialli, Stefano D'Errico
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
AICAR
ZMP
acadesine
AMPK
AMPK activation
imidazole nucleosides
nucleoside analogues
modified nucleosides
acyclic nucleosides
acyclic nucleotides
Online Access:http://www.mdpi.com/1420-3049/18/8/9420

Internet

http://www.mdpi.com/1420-3049/18/8/9420

Similar Items