Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures...

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Main Authors:	Min Zhao, Shimiao Cheng, Weiping Yuan, Yiyuan Xi, Xiubao Li, Jianyong Dong, Kexin Huang, Kirk R. Gustafson, Pengcheng Yan
Format:	Article
Language:	English
Published:	MDPI AG 2016-06-01
Series:	Marine Drugs
Subjects:	soft coral Lobophytum crassum cembrane-based diterpenes NO inhibition
Online Access:	http://www.mdpi.com/1660-3397/14/6/111

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spelling	doaj-ab6b9b9d2e824c11a2dae5b1df8af08c2020-11-24T22:53:35ZengMDPI AGMarine Drugs1660-33972016-06-0114611110.3390/md14060111md14060111Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassumMin Zhao0Shimiao Cheng1Weiping Yuan2Yiyuan Xi3Xiubao Li4Jianyong Dong5Kexin Huang6Kirk R. Gustafson7Pengcheng Yan8School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaThe Fifth Affiliated Hospital, Wenzhou Medical University, Lishui 323000, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaKey Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaMolecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USASchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaTen new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM.http://www.mdpi.com/1660-3397/14/6/111soft coralLobophytum crassumcembrane-based diterpenesNO inhibition
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Min Zhao Shimiao Cheng Weiping Yuan Yiyuan Xi Xiubao Li Jianyong Dong Kexin Huang Kirk R. Gustafson Pengcheng Yan
spellingShingle	Min Zhao Shimiao Cheng Weiping Yuan Yiyuan Xi Xiubao Li Jianyong Dong Kexin Huang Kirk R. Gustafson Pengcheng Yan Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum Marine Drugs soft coral Lobophytum crassum cembrane-based diterpenes NO inhibition
author_facet	Min Zhao Shimiao Cheng Weiping Yuan Yiyuan Xi Xiubao Li Jianyong Dong Kexin Huang Kirk R. Gustafson Pengcheng Yan
author_sort	Min Zhao
title	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
title_short	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
title_full	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
title_fullStr	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
title_full_unstemmed	Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
title_sort	cembranoids from a chinese collection of the soft coral lobophytum crassum
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2016-06-01
description	Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM.
topic	soft coral Lobophytum crassum cembrane-based diterpenes NO inhibition
url	http://www.mdpi.com/1660-3397/14/6/111
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Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

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