DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.

DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder, characterized by the degeneration of motor neurons. Oxidative stress plays a central role in the disease progression, in concert with an enhanced glutamate excitotoxicity and neuroinflammation. DJ-1 mutations,...

Full description

Bibliographic Details
Main Authors: Nirit Lev, Yael Barhum, Itay Lotan, Israel Steiner, Daniel Offen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4379040?pdf=render

Similar Items

Similar Items