Resultados del tratamiento inductivo en el cáncer de pulmón de células no pequeñas localmente avanzado Results of the inductive treatment of locally advanced non-small cell lung cancer

• Format: Article
• Language: Spanish
• Published: Editorial Ciencias Médicas 2007-09-01
• Series: Revista Cubana de Cirugía
• Subjects: neoadjuvant treatment; inductive treatment; platinum-based concurrent radiochemotherapy
• Online Access: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932007000300002

<abstract language="eng">Forty-four patients with locally advanced non-small cell lung cancer, who had received platinum-based radiochemotherapy for surgery induction, were assessed. Nine patients (20,5 %) had complete radiological responses and 17 patients(38,6 %) achieved a reduction higher than or equal to half of the tumor´s initial diameter in its greater axis. The complete or partial radiological response was predictive of resectability (p = 0,048) and associated to better pathological responses (p = 0,031). Four patients (9,9 %) reached histological remission whereas 25 (31,3 %) had partial pathological responses. Pathological sterilization of the ganglionary groups was observed in 23 (74,1 %) of 31 affected subjects. Complete resection was applied in 39 patients (88,6 %), morbidity was acceptable and no post-operative deaths occured. The neoadjuvant treatment was useful for this group of patients since it induced the pathological response and also increased the resectability possibilities