An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions

An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions

Abstract Balancing cell death is essential to maintain healthy tissue homeostasis and prevent disease. Tumor necrosis factor (TNF) not only activates nuclear factor κB (NFκB), which coordinates the cellular response to inflammation, but may also trigger necroptosis, a pro‐inflammatory form of cell d...

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Bibliographic Details
Main Authors: Marie Oliver Metzig, Ying Tang, Simon Mitchell, Brooks Taylor, Robert Foreman, Roy Wollman, Alexander Hoffmann
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Molecular Systems Biology
Subjects:
A20
computational modeling
necroptosis fate decisions
NFκB dynamics
TNF
Online Access:https://doi.org/10.15252/msb.20209677

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