Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype

Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype

Breast and prostate cancers preferentially metastasise to bone tissue, with metastatic lesions forming in the skeletons of most patients. On arriving in bone tissue, disseminated tumour cells enter a mechanical microenvironment that is substantially different to that of the primary tumour and is lar...

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Bibliographic Details
Main Authors: Stefaan W. Verbruggen, Clare L. Thompson, Michael P. Duffy, Sophia Lunetto, Joanne Nolan, Oliver M. T. Pearce, Christopher R. Jacobs, Martin M. Knight
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
breast cancer
prostate cancer
tumour metastasis
bone metastatic disease
cell co-culture
mechanical stimulation
Online Access:https://www.mdpi.com/2072-6694/13/12/2906

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