Transforming Growth Factor Beta 1 Drives a Switch in Connexin Mediated Cell-to-Cell Communication in Tubular Cells of the Diabetic Kidney

Transforming Growth Factor Beta 1 Drives a Switch in Connexin Mediated Cell-to-Cell Communication in Tubular Cells of the Diabetic Kidney

Background/Aims: Changes in cell-to-cell communication have been linked to several secondary complications of diabetes, but the mechanism by which connexins affect disease progression in the kidney is poorly understood. This study examines a role for glucose-evoked changes in the beta1 isoform of tr...

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Bibliographic Details
Main Authors: Claire Hills, Gareth William Price, Mark John Wall, Timothy John Kaufmann, Sidney Chi-wai Tang, Wai Han Yiu, Paul Edward Squires
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
ATP
Inflammation
Fibrosis
Diabetic nephropathy
Tubular epithelia
TGFβ
Connexin
Bio-sensing
Hemi-channels
Gap-junctions
Online Access:https://www.karger.com/Article/FullText/488185

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