Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits

Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits

The rearrangement of the transfection (<i>RET</i>) gene, which mediates the functions of the ganglion in the gastrointestinal tract, plays an important role in the development of the gastrointestinal nervous system. Therefore, the <i>RET</i> gene is a potential factor influen...

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Main Authors: Yuan Gao, Bizhi Huang, Fuxia Bai, Fei Wu, Zihui Zhou, Zhenyu Lai, Shipeng Li, Kaixing Qu, Yutang Jia, Chuzhao Lei, Ruihua Dang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Animals
Subjects:
<i>ret</i> gene
snp
body measurement trait
cattle
Online Access:https://www.mdpi.com/2076-2615/9/10/836
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spelling doaj-ab308911e9a24c87958dabc84dab42a52020-11-24T22:08:50ZengMDPI AGAnimals2076-26152019-10-0191083610.3390/ani9100836ani9100836Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement TraitsYuan Gao0Bizhi Huang1Fuxia Bai2Fei Wu3Zihui Zhou4Zhenyu Lai5Shipeng Li6Kaixing Qu7Yutang Jia8Chuzhao Lei9Ruihua Dang10Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaYunnan Academy of Grassland and Animal Science, Kunming 650212, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaYunnan Academy of Grassland and Animal Science, Kunming 650212, ChinaInstitute of Animal Science and Veterinary Medicine, Anhui Academy of Agriculture Science, Hefei 230001, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, Yangling, Xianyang 712100, Shaanxi, ChinaThe rearrangement of the transfection (<i>RET</i>) gene, which mediates the functions of the ganglion in the gastrointestinal tract, plays an important role in the development of the gastrointestinal nervous system. Therefore, the <i>RET</i> gene is a potential factor influencing animal body measurement. The aim of this study was to reveal the significant genetic variations in the bovine <i>RET</i> gene and investigate the relationship between genotypes and body measurement in two Chinese cattle breeds (Qinchuan and Nanyang cattle). In this study, two SNPs (c.1407A&gt;G and c.1425C&gt;G) were detected in the exon 7 of <i>RET</i> gene by sequencing. For the SNP1 and SNP2, the GG genotype was significantly associated with body height, hip height, and chest circumference in Qinchuan cattle (<i>p</i> &lt; 0.05). Individuals with an AG-CC genotype showed the lowest value of all body measurement in both breeds. Our results demonstrate that the polymorphisms in the bovine <i>RET</i> gene were significantly associated with body measurement, which could be used as DNA marker on the marker-assisted selection (MAS) and improve the performance of beef cattle.https://www.mdpi.com/2076-2615/9/10/836<i>ret</i> genesnpbody measurement traitcattle
collection DOAJ
language English
format Article
sources DOAJ
author Yuan Gao
Bizhi Huang
Fuxia Bai
Fei Wu
Zihui Zhou
Zhenyu Lai
Shipeng Li
Kaixing Qu
Yutang Jia
Chuzhao Lei
Ruihua Dang
spellingShingle Yuan Gao
Bizhi Huang
Fuxia Bai
Fei Wu
Zihui Zhou
Zhenyu Lai
Shipeng Li
Kaixing Qu
Yutang Jia
Chuzhao Lei
Ruihua Dang
Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
Animals
<i>ret</i> gene
snp
body measurement trait
cattle
author_facet Yuan Gao
Bizhi Huang
Fuxia Bai
Fei Wu
Zihui Zhou
Zhenyu Lai
Shipeng Li
Kaixing Qu
Yutang Jia
Chuzhao Lei
Ruihua Dang
author_sort Yuan Gao
title Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
title_short Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
title_full Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
title_fullStr Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
title_full_unstemmed Two Novel SNPs in <i>RET</i> Gene Are Associated with Cattle Body Measurement Traits
title_sort two novel snps in <i>ret</i> gene are associated with cattle body measurement traits
publisher MDPI AG
series Animals
issn 2076-2615
publishDate 2019-10-01
description The rearrangement of the transfection (<i>RET</i>) gene, which mediates the functions of the ganglion in the gastrointestinal tract, plays an important role in the development of the gastrointestinal nervous system. Therefore, the <i>RET</i> gene is a potential factor influencing animal body measurement. The aim of this study was to reveal the significant genetic variations in the bovine <i>RET</i> gene and investigate the relationship between genotypes and body measurement in two Chinese cattle breeds (Qinchuan and Nanyang cattle). In this study, two SNPs (c.1407A&gt;G and c.1425C&gt;G) were detected in the exon 7 of <i>RET</i> gene by sequencing. For the SNP1 and SNP2, the GG genotype was significantly associated with body height, hip height, and chest circumference in Qinchuan cattle (<i>p</i> &lt; 0.05). Individuals with an AG-CC genotype showed the lowest value of all body measurement in both breeds. Our results demonstrate that the polymorphisms in the bovine <i>RET</i> gene were significantly associated with body measurement, which could be used as DNA marker on the marker-assisted selection (MAS) and improve the performance of beef cattle.
topic <i>ret</i> gene
snp
body measurement trait
cattle
url https://www.mdpi.com/2076-2615/9/10/836
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