Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis

Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis

Targeting non-apoptotic modalities might be therapeutically promising in diffuse large B cell lymphoma (DLBCL) patients with compromised apoptotic pathways. Thymoquinone (TQ) has been reported to promote apoptosis in cancer cells, but little is known about its effect on non-apoptotic pathways. This...

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Bibliographic Details
Main Authors: Mimoune Berehab, Redouane Rouas, Haidar Akl, Hugues Duvillier, Fabrice Journe, Hussein Fayyad-Kazan, Ghanem Ghanem, Dominique Bron, Philippe Lewalle, Makram Merimi
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
thymoquinone
diffuse large B cell lymphoma (DLBCL)
apoptosis
ER-stress
non-apoptotic cell death
necroptosis
Online Access:https://www.mdpi.com/2072-6694/13/14/3579

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