Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease

Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease

A newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial vill...

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Main Authors: Wendy Wilson, R Brent Scott, Alfredo Pinto, Marli A Robertson
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2001/743925
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spelling doaj-ab2aa3895e7c4baabdfca6643532e0062020-11-24T23:14:48ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002001-01-01151616410.1155/2001/743925Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion DiseaseWendy Wilson0R Brent Scott1Alfredo Pinto2Marli A Robertson3Department of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Pathology, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaA newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial villous atrophy and crypt hypoplasia. Ultrastructural studies of the villous enterocyte revealed internalized inclusions of microvilli, typical of microvillous inclusion disease. Presented are a case report and a discussion of the differential diagnosis of watery diarrhea in the neonate, as well as a short review of microvillous inclusion disease.http://dx.doi.org/10.1155/2001/743925
collection DOAJ
language English
format Article
sources DOAJ
author Wendy Wilson
R Brent Scott
Alfredo Pinto
Marli A Robertson
spellingShingle Wendy Wilson
R Brent Scott
Alfredo Pinto
Marli A Robertson
Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
Canadian Journal of Gastroenterology
author_facet Wendy Wilson
R Brent Scott
Alfredo Pinto
Marli A Robertson
author_sort Wendy Wilson
title Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
title_short Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
title_full Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
title_fullStr Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
title_full_unstemmed Intractable Diarrhea in a Newborn Infant: Microvillous Inclusion Disease
title_sort intractable diarrhea in a newborn infant: microvillous inclusion disease
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2001-01-01
description A newborn male presented with watery diarrhea, dehydration and metabolic acidosis. Severe secretory diarrhea of variable magnitude persisted when the patient was on parenteral nutrition with no oral intake. Initial light microscopic evaluation of a small intestinal mucosal biopsy showed partial villous atrophy and crypt hypoplasia. Ultrastructural studies of the villous enterocyte revealed internalized inclusions of microvilli, typical of microvillous inclusion disease. Presented are a case report and a discussion of the differential diagnosis of watery diarrhea in the neonate, as well as a short review of microvillous inclusion disease.
url http://dx.doi.org/10.1155/2001/743925
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AT alfredopinto intractablediarrheainanewborninfantmicrovillousinclusiondisease
AT marliarobertson intractablediarrheainanewborninfantmicrovillousinclusiondisease
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