Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen

Oral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide. The molecular mechanisms related to the pathogenesis of this disease are still poorly understood. The discovery of a molecular marker that allows the e...

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Main Authors: Gabriella Aquino, Rocco Sabatino, Monica Cantile, Corrado Aversa, Franco Ionna, Gerardo Botti, Elvira La Mantia, Francesca Collina, Gabriella Malzone, Giuseppe Pannone, Nunzia Simona Losito, Renato Franco, Francesco Longo
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/736438
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spelling doaj-ab2749b3df9140b7a52dc29f784645272020-11-24T20:54:22ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/736438736438Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical SpecimenGabriella Aquino0Rocco Sabatino1Monica Cantile2Corrado Aversa3Franco Ionna4Gerardo Botti5Elvira La Mantia6Francesca Collina7Gabriella Malzone8Giuseppe Pannone9Nunzia Simona Losito10Renato Franco11Francesco Longo12Pathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyHead and Neck Medical Oncology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyHead and Neck Medical Oncology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyDepartment of Surgical Sciences, Section of Anatomic Pathology, Second Section of Oral Pathology, University of Foggia, Foggia, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyPathology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyHead and Neck Medical Oncology Unit, Istituto Nazionale Tumori “Fondazione Pascale”-IRCCS, Napoli, ItalyOral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide. The molecular mechanisms related to the pathogenesis of this disease are still poorly understood. The discovery of a molecular marker that allows the early detection of this cancer, which can be easily identified in biological samples, such as saliva, without intervening in advanced stages, is a challenge. Numerous studies have identified a panel of molecular markers differently expressed in OSCC and normal oral mucosa. In particular, it was found an aberrant expression of matricellular glycoprotein SPARC. SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation. In fact, aberrant SPARC expression was detected both in stromal cells associated with cancer and in tumor cells. The aim of our study was the evaluation of SPARC on a retrospective series of 119 OSCC cases and the validation of the obtained data on a prospective series of 27 patients with OSCC, of whom we have previously collected saliva, and smeared material. The obtained results were correlated with each other and with clinical pathological parameters at our disposal. The study demonstrated a prognostic value of SPARC, especially with regard to its expression in the stroma surrounding OSCC (P < 0.05).http://dx.doi.org/10.1155/2013/736438
collection DOAJ
language English
format Article
sources DOAJ
author Gabriella Aquino
Rocco Sabatino
Monica Cantile
Corrado Aversa
Franco Ionna
Gerardo Botti
Elvira La Mantia
Francesca Collina
Gabriella Malzone
Giuseppe Pannone
Nunzia Simona Losito
Renato Franco
Francesco Longo
spellingShingle Gabriella Aquino
Rocco Sabatino
Monica Cantile
Corrado Aversa
Franco Ionna
Gerardo Botti
Elvira La Mantia
Francesca Collina
Gabriella Malzone
Giuseppe Pannone
Nunzia Simona Losito
Renato Franco
Francesco Longo
Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
BioMed Research International
author_facet Gabriella Aquino
Rocco Sabatino
Monica Cantile
Corrado Aversa
Franco Ionna
Gerardo Botti
Elvira La Mantia
Francesca Collina
Gabriella Malzone
Giuseppe Pannone
Nunzia Simona Losito
Renato Franco
Francesco Longo
author_sort Gabriella Aquino
title Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
title_short Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
title_full Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
title_fullStr Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
title_full_unstemmed Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
title_sort expression analysis of sparc/osteonectin in oral squamous cell carcinoma patients: from saliva to surgical specimen
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Oral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide. The molecular mechanisms related to the pathogenesis of this disease are still poorly understood. The discovery of a molecular marker that allows the early detection of this cancer, which can be easily identified in biological samples, such as saliva, without intervening in advanced stages, is a challenge. Numerous studies have identified a panel of molecular markers differently expressed in OSCC and normal oral mucosa. In particular, it was found an aberrant expression of matricellular glycoprotein SPARC. SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation. In fact, aberrant SPARC expression was detected both in stromal cells associated with cancer and in tumor cells. The aim of our study was the evaluation of SPARC on a retrospective series of 119 OSCC cases and the validation of the obtained data on a prospective series of 27 patients with OSCC, of whom we have previously collected saliva, and smeared material. The obtained results were correlated with each other and with clinical pathological parameters at our disposal. The study demonstrated a prognostic value of SPARC, especially with regard to its expression in the stroma surrounding OSCC (P < 0.05).
url http://dx.doi.org/10.1155/2013/736438
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