APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells

APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells

Proliferating cell nuclear antigen (PCNA) is essential for the organization of DNA replication and the bypass of DNA lesions via translesion synthesis (TLS). TLS is mediated by specialized DNA polymerases, which all interact, directly or indirectly, with PCNA. How interactions between the TLS polyme...

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Bibliographic Details
Main Authors: Synnøve Brandt Ræder, Anala Nepal, Karine Øian Bjørås, Mareike Seelinger, Rønnaug Steen Kolve, Aina Nedal, Rebekka Müller, Marit Otterlei
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
POLζ
mutation frequency
mutations spectra
SupF
mutagenicity
Online Access:http://www.mdpi.com/1422-0067/20/1/100

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